Author’s response to reviews Title: MiR-146a G/C rs2910164 variations in South African Indian and Caucasian patients with psoriatic arthritis Authors:
نویسندگان
چکیده
Authors: Ajesh Maharaj ([email protected]) Pragalathan Naidoo ([email protected]) Terisha Ghazi ([email protected]) Naeem Abdul ([email protected]) Shanel Dhani ([email protected]) Taskeen Docrat ([email protected]) Prithiksha Ramkaran ([email protected]) Paul Tak ([email protected]) Niek de Vries ([email protected]) Anil Chuturgoon ([email protected])
منابع مشابه
Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population
OBJECTIVE MicroRNAs (miRNAs) are short regulatory RNAs that can modulate gene expression and function as negative regulators. Common genetic variants like single nucleotide polymorphisms (SNPs) in miRNA genes may alter their expression or maturation resulting in varied functional consequences in carcinogenesis. Therefore, we evaluated the genetic variants in pre-miRNAs: hsa-miR-146a G/C (rs2910...
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Background & Aims: Behcet's disease (BD) is an autoimmune disease that usually occurs with oral, genital and ocular ulcers. The cause of this disease is unknown and environmental, genetic and immunological factors contribute to its development. In the present study, the relation between rs2910164 and rs57095329 polymorphisms of miR146a gene with the potential for BD was investigated in Iranian ...
متن کاملA single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study
Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study investigated the association between a functional...
متن کاملMiR-146a polymorphism correlates with lung cancer risk in Chinese nonsmoking females
This study provides evidence that the common rs2910164 polymorphism in miR-146a strongly correlates with lung cancer risk in nonsmoking females in northeast China. The genotypes of miR-146a rs2910164 were determined in 1131 patients with lung cancer and 1003 healthy control subjects. Tissue samples were used to evaluate the association between miRNA expression and lung cancer risk as well as th...
متن کاملGenetic association of MiR-146a with multiple sclerosis susceptibility in the Chinese population.
BACKGROUND miR-146a polymorphisms have been involved in susceptibility to multiple diseases. The aim of the present study was to analyze the potential association between two functional miR-146a polymorphisms (rs2910164 and rs57095329) and multiple sclerosis (MS) in the Han Chinese population. METHODS A cohort of 525 patients and 568 healthy controls were genotyped to detect the two polymorph...
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